Krit1^tm1Dmar
Targeted Allele Detail

Summary

• Symbol: Krit1^tm1Dmar
• Name: KRIT1, ankyrin repeat containing; targeted mutation 1, Douglas Marchuk
• MGI ID: MGI:2449693
• Synonyms: Ccm1^-
• Gene: Krit1 Location: Chr5:3853156-3894515 bp, + strand Genetic Position: Chr5, 2.26 cM
• Alliance: Krit1^tm1Dmar page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:88138
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The majority of exon 6 and all of exon 7 was replaced with a lacZ reporter cassette, effectively deleting the first ankyrin repeat of the gene. At E8.5, no expression was detected in homozygous mutant mice by in situ hybridization. (J:88138)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Krit1 Mutation: 35 strains or lines available

References

• Original: J:88138 Whitehead KJ, et al., Ccm1 is required for arterial morphogenesis: implications for the etiology of human cavernous malformations. Development. 2004 Mar;131(6):1437-48
• All: 8 reference(s)