Lefty1^tm1Sla
Targeted Allele Detail

Summary

• Symbol: Lefty1^tm1Sla
• Name: left right determination factor 1; targeted mutation 1, Siew-Lan Ang
• MGI ID: MGI:2449694
• Synonyms: Lefty1^EIV
• Gene: Lefty1 Location: Chr1:180762587-180765965 bp, + strand Genetic Position: Chr1, 84.46 cM, cytoband F
• Alliance: Lefty1^tm1Sla page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:81339
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Disruption caused by insertion of vector
• Exon 4, which encodes the mature protein (aa 249-368), was disrupted by homologous recombination. (J:81339)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lefty1 Mutation: 41 strains or lines available

References

• Original: J:81339 Perea-Gomez A, et al., Nodal antagonists in the anterior visceral endoderm prevent the formation of multiple primitive streaks. Dev Cell. 2002 Nov;3(5):745-56
• All: 1 reference(s)