Opn4^tm1Skay
Targeted Allele Detail

Summary

• Symbol: Opn4^tm1Skay
• Name: opsin 4 (melanopsin); targeted mutation 1, Steve A Kay
• MGI ID: MGI:2449695
• Synonyms: Opn4^-, Opn4^neo
• Gene: Opn4 Location: Chr14:34312575-34322099 bp, - strand Genetic Position: Chr14, 20.83 cM, cytoband B
• Alliance: Opn4^tm1Skay page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:81501
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S1/SvImJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1 was replaced with a neomycin selection cassette inserted by homologous recombination. Protein was undetected by immunocytochemical analysis of homozygous mutant retinal tissue. (J:81501)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Opn4 Mutation: 33 strains or lines available

References

• Original: J:81501 Panda S, et al., Melanopsin (Opn4) requirement for normal light-induced circadian phase shifting. Science. 2002 Dec 13;298(5601):2213-6
• All: 23 reference(s)