Opn4tm1Ruby
Targeted Allele Detail
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Symbol: |
Opn4tm1Ruby |
Name: |
opsin 4 (melanopsin); targeted mutation 1, Norman F Ruby |
MGI ID: |
MGI:2449696 |
Gene: |
Opn4 Location: Chr14:34312575-34322099 bp, - strand Genetic Position: Chr14, 20.83 cM, cytoband B
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Alliance: |
Opn4tm1Ruby page
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Germline Transmission: |
Earliest citation of germline transmission:
J:81502
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
129P2/OlaHsd
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Allele Type: |
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Targeted (Null/knockout, Reporter) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: Exon 3 was disrupted by the insertion of a cassette containing IRES-betageo. The deleted region consisted of 38 bp encoding a portion of the predicted transmembrane domain 2 (amino acids 116-128). X-gal staining showed expression of lacZ in occasional cells of the ganglion cell layer.
(J:81502)
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Key: |
hm |
homozygous |
ht |
heterozygous |
tg |
involves transgenes |
√ |
phenotype observed |
cn |
conditional genotype |
cx |
complex: > 1 genome feature |
ot |
other: hemizygous, indeterminate,... |
N |
normal phenotype |
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Genotype/ Background: |
| Allelic Composition | Genetic Background | Cell Line(s) |
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Loading... | | | involves: 129P2/OlaHsd * C57BL/6 | |
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Phenotypes: |
Affected Systems |
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behavior/neurological
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√
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abnormal circadian behavior phase
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√
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Opn4 Mutation: |
33 strains or lines available
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Original: |
J:81502 Ruby NF, et al., Role of melanopsin in circadian responses to light. Science. 2002 Dec 13;298(5601):2211-3 |
All: |
3 reference(s) |
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