Opn4^tm1Ruby
Targeted Allele Detail

Summary

• Symbol: Opn4^tm1Ruby
• Name: opsin 4 (melanopsin); targeted mutation 1, Norman F Ruby
• MGI ID: MGI:2449696
• Gene: Opn4 Location: Chr14:34312575-34322099 bp, - strand Genetic Position: Chr14, 20.83 cM, cytoband B
• Alliance: Opn4^tm1Ruby page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:81502
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 3 was disrupted by the insertion of a cassette containing IRES-betageo. The deleted region consisted of 38 bp encoding a portion of the predicted transmembrane domain 2 (amino acids 116-128). X-gal staining showed expression of lacZ in occasional cells of the ganglion cell layer. (J:81502)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Opn4 Mutation: 33 strains or lines available

References

• Original: J:81502 Ruby NF, et al., Role of melanopsin in circadian responses to light. Science. 2002 Dec 13;298(5601):2211-3
• All: 3 reference(s)