Ctsa^tm1Adz
Targeted Allele Detail

Summary

• Symbol: Ctsa^tm1Adz
• Name: cathepsin A; targeted mutation 1, Alessandro dAzzo
• MGI ID: MGI:2449708
• Synonyms: PPCA(-), PPCA-
• Gene: Ctsa Location: Chr2:164674793-164682952 bp, + strand Genetic Position: Chr2, 85.27 cM
• Alliance: Ctsa^tm1Adz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:29674
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: Exon 2 was disrupted with a hygromycin selection cassette inserted by homologous recombination. Transcript was undetected by Northern blot analysis of homozygous mutant mice. (J:29674)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ctsa Mutation: 30 strains or lines available

References

• Original: J:29674 Zhou XY, et al., Mouse model for the lysosomal disorder galactosialidosis and correction of the phenotype with overexpressing erythroid precursor cells. Genes Dev. 1995 Nov 1;9(21):2623-34
• All: 7 reference(s)