Anxa1^tm1Rjf
Targeted Allele Detail

Summary

• Symbol: Anxa1^tm1Rjf
• Name: annexin A1; targeted mutation 1, Roderick J Flower
• MGI ID: MGI:2449710
• Synonyms: annexin 1-, Anx-1-, AnxA1^(-), ANXA1 KO
• Gene: Anxa1 Location: Chr19:20350798-20368035 bp, - strand Genetic Position: Chr19, 13.83 cM
• Alliance: Anxa1^tm1Rjf page

Anxa1^tm1Rjf/Anxa1^tm1Rjf mice exhibit a delay in colonic mucosal wound closure

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:81498
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A portion of exon 2 and all of exons 3 and 4 were replaced with a cassette containing lacZ and PGK-neo. Endogenous protein was undetected in homozygous mutant mice. lacZ expression was detected in various tissues. (J:81498)

Expression

In Mice Carrying this Mutation:	10 assay results
In Structures Affected by this Mutation:	12 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Anxa1 Mutation: 25 strains or lines available

References

• Original: J:81498 Hannon R, et al., Aberrant inflammation and resistance to glucocorticoids in annexin 1-/- mouse. FASEB J. 2003 Feb;17(2):253-5
• All: 68 reference(s)