Opn4^tm1Yau
Targeted Allele Detail

Summary

• Symbol: Opn4^tm1Yau
• Name: opsin 4 (melanopsin); targeted mutation 1, King-Wai Yau
• MGI ID: MGI:2449781
• Synonyms: MKO, mop^-, Opn4-, Opn4^taulac, Opn4^tau-lacZ
• Gene: Opn4 Location: Chr14:34312575-34322099 bp, - strand Genetic Position: Chr14, 20.83 cM, cytoband B
• Alliance: Opn4^tm1Yau page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:81604
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: The endogenous locus was disrupted by the insertion of a cassette containing tau-lacZ and floxed PGK-neo immediately downstream of the endogenous start codon. Beta-galactosidase activity verified the expression of lacZ. (J:81604)

Expression

In Mice Carrying this Mutation:

30 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Opn4 Mutation: 33 strains or lines available

References

• Original: J:81604 Hattar S, et al., Melanopsin-containing retinal ganglion cells: architecture, projections, and intrinsic photosensitivity. Science. 2002 Feb 8;295(5557):1065-70
• All: 80 reference(s)