Kit^tm1Alf
Targeted Allele Detail

Summary

• Symbol: Kit^tm1Alf
• Name: KIT proto-oncogene receptor tyrosine kinase; targeted mutation 1, Jean-Jacques Panthier
• MGI ID: MGI:2449782
• Synonyms: kit^W-lacZ, W^lacZ
• Gene: Kit Location: Chr5:75735647-75817382 bp, + strand Genetic Position: Chr5, 39.55 cM
• Alliance: Kit^tm1Alf page

Germ cell phenotypes of Kit^Mhdasco1/Kit^Mhdasco1, Kit^Mhdasow3/Kit^Mhdasow3, Kit^Mhdasco5/Kit^Mhdasco5, Kit^tm1Alf/Kit^Mhdasow3 and Kit^Whc1/Kit^Whc1 mice

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:36230
• Parent Cell Line: CK35 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The gene was disrupted by replacement of exon 1 (codons 7-22) and 200 bp of intron 1 with a lacZ-neo cassette via homologous recombination. No residual protein product or mRNA was detected in homozygous mutant animals. (J:36230)

Expression

In Mice Carrying this Mutation:	37 assay results
In Structures Affected by this Mutation:	9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Kit Mutation: 182 strains or lines available

References

• Original: J:36230 Bernex F, et al., Spatial and temporal patterns of c-kit-expressing cells in WlacZ/+ and WlacZ/WlacZ mouse embryos. Development. 1996 Oct;122(10):3023-33
• All: 20 reference(s)