Erbb2^{tm3(Erbb2)Mul}
Targeted Allele Detail

Summary

• Symbol: Erbb2^{tm3(Erbb2)Mul}
• Name: erb-b2 receptor tyrosine kinase 2; targeted mutation 3, William Muller
• MGI ID: MGI:2449788
• Synonyms: ErbB2^Flox
• Gene: Erbb2 Location: Chr11:98303310-98328542 bp, + strand Genetic Position: Chr11, 61.75 cM, cytoband D
• Alliance: Erbb2^{tm3(Erbb2)Mul} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:81565
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, Inserted expressed sequence)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1 was replaced with a loxP-flanked rat Erbb2 cDNA followed by a neomycin selection cassette. Immunoprecipitation and western blot analysis demonstrated that a reduced level of expressed protein was present in muscle extracts derived from homozygous mice. Crossing mice carrying this allele with mice expressing Cre recombinase is expected to eliminate expression from this allele. (J:81565)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Erbb2 Mutation: 61 strains or lines available

References

• Original: J:81565 Andrechek ER, et al., ErbB2 is required for muscle spindle and myoblast cell survival. Mol Cell Biol. 2002 Jul;22(13):4714-22
• All: 4 reference(s)