Zar1^tm1Zuk
Targeted Allele Detail

Summary

• Symbol: Zar1^tm1Zuk
• Name: zygote arrest 1; targeted mutation 1, Martin M Matzuk
• MGI ID: MGI:2449829
• Synonyms: Zar1^-
• Gene: Zar1 Location: Chr5:72734457-72738427 bp, - strand Genetic Position: Chr5, 38.44 cM
• Alliance: Zar1^tm1Zuk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:81447
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The gene was disrupted by replacement of exon 1 and part of intron 1 with a PGK-HPRT cassette via homologous recombination. Absence of normal transcripts was confirmed by Northern blot analysis of ovary mRNA from homozygous mutant animals using the full cDNA as a probe. Longer exposure of the Northern blot revealed a smaller transcript of unknown relevance. (J:81447)

Expression

In Mice Carrying this Mutation:	6 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Zar1 Mutation: 17 strains or lines available

References

• Original: J:81447 Wu X, et al., Zygote arrest 1 (Zar1) is a novel maternal-effect gene critical for the oocyte-to-embryo transition. Nat Genet. 2003 Feb;33(2):187-91
• All: 2 reference(s)