Nr1d1^tm1Ven
Targeted Allele Detail

Summary

• Symbol: Nr1d1^tm1Ven
• Name: nuclear receptor subfamily 1, group D, member 1; targeted mutation 1, Bjorn Vennstrom
• MGI ID: MGI:2449852
• Synonyms: Rev-erb-alpha^-
• Gene: Nr1d1 Location: Chr11:98658758-98666159 bp, - strand Genetic Position: Chr11, 62.66 cM
• Alliance: Nr1d1^tm1Ven page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:60839
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Part of exon 2, exons 3-5, and part of exon 6 were replaced with a lacZ-neo cassette via homologous recombination. The targeted mutation deletes exons encoding the DNA binding domains. Absence of gene expression was confirmed by Northern blot analysis of midbrain/forbrain and cerebellum RNA from P10 and P13 homozygous mutant animals. (J:60839)

Expression

In Mice Carrying this Mutation:	5 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Nr1d1 Mutation: 42 strains or lines available

References

• Original: J:60839 Chomez P, et al., Increased cell death and delayed development in the cerebellum of mice lacking the rev-erbA(alpha) orphan receptor. Development. 2000 Apr;127(7):1489-98
• All: 38 reference(s)