Tll1^tm1Dgr
Targeted Allele Detail

Summary

• Symbol: Tll1^tm1Dgr
• Name: tolloid-like; targeted mutation 1, Daniel S Greenspan
• MGI ID: MGI:2449853
• Synonyms: Tll1^-/-
• Gene: Tll1 Location: Chr8:64467965-64659305 bp, - strand Genetic Position: Chr8, 32.19 cM
• Alliance: Tll1^tm1Dgr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:54910
• Parent Cell Line: TL1/TL-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The gene was disrupted by replacement of exon 6, which encodes the zinc-binding active site, with a neomycin resistance gene resulting in a frameshift mutation and premature stop codon. RT-PCR analysis of RNA from whole homozygous mutant embryos at day E13.5 confirmed the absence of gene expression. (J:54910)

Expression

In Mice Carrying this Mutation:	2 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	10 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tll1 Mutation: 70 strains or lines available

References

• Original: J:54910 Clark TG, et al., The mammalian Tolloid-like 1 gene, Tll1, is necessary for normal septation and positioning of the heart. Development. 1999 Jun;126(12):2631-42
• All: 3 reference(s)