Hhex^tm1Cwb
Targeted Allele Detail

Summary

• Symbol: Hhex^tm1Cwb
• Name: hematopoietically expressed homeobox; targeted mutation 1, Clifford W Bogue
• MGI ID: MGI:2449914
• Synonyms: Hex^-
• Gene: Hhex Location: Chr19:37423289-37429179 bp, + strand Genetic Position: Chr19, 32.28 cM, cytoband D1
• Alliance: Hhex^tm1Cwb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:81415
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The gene was disrupted by replacement of exons 1 and 2 with a PGK-neo cassette via homologous recombination. (J:81415)

Expression

In Mice Carrying this Mutation:	44 assay results
In Structures Affected by this Mutation:	17 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hhex Mutation: 17 strains or lines available

Notes

ES cell line = JET (James McGrath, unpublished results).

References

• Original: J:81415 Bogue CW, et al., Impaired B cell development and function in mice with a targeted disruption of the homeobox gene Hex. Proc Natl Acad Sci U S A. 2003 Jan 21;100(2):556-61
• All: 11 reference(s)