Sema3a^tm1Mcf
Targeted Allele Detail

Summary

• Symbol: Sema3a^tm1Mcf
• Name: sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A; targeted mutation 1, Mark C Fishman
• MGI ID: MGI:2449920
• Gene: Sema3a Location: Chr5:13175381-13652533 bp, + strand Genetic Position: Chr5, 4.31 cM
• Alliance: Sema3a^tm1Mcf page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:35824
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The exon containing the start codon and encoding 38 amino acids was replaced with a neomycin selection cassette inserted by homologous recombination. Northern blot analysis showed low levels of transcript in homozygous mutant mice. (J:35824)

Expression

In Mice Carrying this Mutation:	52 assay results
In Structures Affected by this Mutation:	8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sema3a Mutation: 48 strains or lines available

References

• Original: J:35824 Behar O, et al., Semaphorin III is needed for normal patterning and growth of nerves, bones and heart. Nature. 1996 Oct 10;383(6600):525-8
• All: 21 reference(s)