Gfi1^tm1Sho
Targeted Allele Detail

Summary

• Symbol: Gfi1^tm1Sho
• Name: growth factor independent 1 transcription repressor; targeted mutation 1, Stuart Orkin
• MGI ID: MGI:2449921
• Synonyms: Gfi-1^-, Gfi1^deltaex2-3
• Gene: Gfi1 Location: Chr5:107864521-107873671 bp, - strand Genetic Position: Chr5, 52.23 cM
• Alliance: Gfi1^tm1Sho page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:81364
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Sequence encompassing the start codon in exon 1 and all of exons 2 and 3 was replaced by a floxed neo cassette inserted by homologous recombination. The neo cassette was subsequently excised via in vivo cre mediated recombination in the germ line. (J:81364)

Expression

In Mice Carrying this Mutation:	22 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gfi1 Mutation: 31 strains or lines available

References

• Original: J:81364 Hock H, et al., Intrinsic requirement for zinc finger transcription factor gfi-1 in neutrophil differentiation. Immunity. 2003 Jan;18(1):109-20
• All: 24 reference(s)