Fev^tm1Esd
Targeted Allele Detail

Summary

• Symbol: Fev^tm1Esd
• Name: FEV transcription factor, ETS family member; targeted mutation 1, Evan S Deneris
• MGI ID: MGI:2449922
• Synonyms: Pet-1^-, Pet1^-, Pet-1 KO
• Gene: Fev Location: Chr1:74920668-74924578 bp, - strand
• Alliance: Fev^tm1Esd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:81450
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The entire coding region was replaced with a neomycin selection cassette inserted by homologous recombination. Transcript was undetected by in situ hybridization of hindbrain tissue obtained from homozygous mutant mice. (J:81450)

Expression

In Mice Carrying this Mutation:

18 assay results 1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fev Mutation: 14 strains or lines available

References

• Original: J:81450 Hendricks TJ, et al., Pet-1 ETS Gene Plays a Critical Role in 5-HT Neuron Development and Is Required for Normal Anxiety-like and Aggressive Behavior. Neuron. 2003 Jan 23;37(2):233-47
• All: 32 reference(s)