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Gzmatm1Simn
Targeted Allele Detail
Summary
Symbol: Gzmatm1Simn
Name: granzyme A; targeted mutation 1, Markus M Simon
MGI ID: MGI:2449926
Synonyms: GrzA-, gzm A-, gzmA-
Gene: Gzma  Location: Chr13:113230359-113237515 bp, - strand  Genetic Position: Chr13, 63.93 cM, cytoband D
Alliance: Gzmatm1Simn page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:28773
Parent Cell Line:  BL/6-III (ES Cell)
Strain of Origin:  C57BL/6
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsThe gene was disrupted by insertion of a neomycin resistance cassette into exon 4 by homologous recombination. Western blot analysis confirmed the absence of protein product and cytochemical analysis demonstrated the absence of enzyme activity in cytotoxic T cells in homozygous mutant animals. (J:28773)
Phenotypes
Key:
hm homozygous ht heterozygous tg involves transgenes phenotype observed
cn conditional genotype  cx complex: > 1 genome feature ot other: hemizygous, indeterminate,... N normal phenotype
Genotype/
Background:
Allelic Composition
Genetic Background
Cell Line(s)
Allelic CompositionGenetic BackgroundCell Line(s)
B6.Cg-Gzmatm1Simn
 
B6.Cg-Gzmatm1Simn Gzmbtm1Ley
 
B6.Cg-Gzmatm1Simn Gzmbtm1Ley Prf1tm1Sdz
 
involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6
 
involves: 129S2/SvPas * C57BL/6
 
Phenotypes:
Affected Systems
show or hide all annotated terms
         
hematopoietic system
N
hematopoietic system phenotype
N
abnormal leukocyte physiology
immune system
N
immune system phenotype
N N N N
abnormal leukocyte physiology
increased susceptibility to parasitic infection
increased susceptibility to Flaviviridae infection
mortality/aging
increased susceptibility to induced morbidity/mortality
neoplasm
N
neoplasm
N
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 8 strains available      Cell Lines: 0 lines available
Carrying any Gzma Mutation:  34 strains or lines available
References
Original:  J:28773 Ebnet K, et al., Granzyme A-deficient mice retain potent cell-mediated cytotoxicity. EMBO J. 1995 Sep 1;14(17):4230-9
All:  53 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/17/2024
MGI 6.24
The Jackson Laboratory