Gzma^tm1Simn
Targeted Allele Detail

Summary

• Symbol: Gzma^tm1Simn
• Name: granzyme A; targeted mutation 1, Markus M Simon
• MGI ID: MGI:2449926
• Synonyms: GrzA-, gzm A-, gzmA-
• Gene: Gzma Location: Chr13:113230359-113237515 bp, - strand Genetic Position: Chr13, 63.93 cM, cytoband D
• Alliance: Gzma^tm1Simn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:28773
• Parent Cell Line: BL/6-III (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: The gene was disrupted by insertion of a neomycin resistance cassette into exon 4 by homologous recombination. Western blot analysis confirmed the absence of protein product and cytochemical analysis demonstrated the absence of enzyme activity in cytotoxic T cells in homozygous mutant animals. (J:28773)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 8 strains available Cell Lines: 0 lines available
• Carrying any Gzma Mutation: 34 strains or lines available

References

• Original: J:28773 Ebnet K, et al., Granzyme A-deficient mice retain potent cell-mediated cytotoxicity. EMBO J. 1995 Sep 1;14(17):4230-9
• All: 53 reference(s)