Commd10^{Tg(Vav1-icre)A2Kio}
Transgenic Allele Detail

Summary

• Symbol: Commd10^{Tg(Vav1-icre)A2Kio}
• Name: COMM domain containing 10; transgene insertion A2, Dimitris Kioussis
• MGI ID: MGI:2449949
• Synonyms: Tg(Vav1-cre)1Kio, Tg(Vav1-cre)A2Kio, Tg(Vav1-icre)A2Kio, Vav1-Cre, Vav1 (HS21/5)-iCre, Vav-cre, VavCre, VavCre^deBoer, Vav-iCre
• Gene: Commd10 Location: Chr18:47091917-47242435 bp, + strand Genetic Position: Chr18, 24.9 cM
• Alliance: Commd10^{Tg(Vav1-icre)A2Kio} page

Transgene origin

• Strain of Origin: (CBA/Ca x C57BL/10)F2

Transgene description

• Transgene Type: Transgenic (Null/knockout, Recombinase)
• Mutation: Insertion
• Commd10^{Tg(Vav1-icre)A2Kio} expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  Not Specified	Vav1

• Mutation details: This transgene expresses Cre recombinase under the control of a vav promoter. This promoter was shown to be active in lymph nodes, thymus, spleen, Peyer's patches, intestinal cryptopatches, ovaries and testes. Line A2 inserted into the gene at 47022629-47022630 (Build GRCm38/mm10). The insetion results in a functional knock-out in homozygous mice. (J:81568)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Vav1 (species not specified) Summary of all recombinase alleles driven by Vav1. Comparative matrix view of recombinase activities

Disease models

Expression

In Mice Carrying this Mutation:

28 assay results 19 RNA-Seq or microarray experiment(s)

Tumor Data

List all tumor models in MMHCdb carrying Commd10^{Tg(Vav1-icre)A2Kio}

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Commd10 Mutation: 24 strains or lines available

References

• Original: J:81568 De Boer J, et al., Transgenic mice with hematopoietic and lymphoid specific expression of Cre. Eur J Immunol. 2003 Feb;33(2):314-25
• All: 577 reference(s)