a^{jIs(17;In2)1Gso}
Radiation induced Allele Detail

Summary

• Symbol: a^{jIs(17;In2)1Gso}
• Name: nonagouti; nonagouti insertion 1 Generoso
• MGI ID: MGI:2450142
• Synonyms: Is1Gso
• Gene: a Location: Chr2:154792519-154892932 bp, + strand Genetic Position: Chr2, 76.83 cM
• Alliance: a^{jIs(17;In2)1Gso} page

Mutation origin

• Strain of Origin: (C3H/Rl x 101/Rl)F1

Mutation description

• Allele Type: Radiation induced
• Mutation: Translocation
• Inheritance: Recessive

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any a Mutation: 463 strains or lines available

Notes

This allele is the result of a major chromosomal alteration: An interstitial segment of Chromosome 17 (17B-17C or 17A2-17B) has been translocated into the distal end of Chromosome 2, adjacent and distal to an inverted segment of Chromosome 2 (2E4-2H1). The distal break in Chromosome 2 disrupted the A (or A^w) locus producing a mutation to a^j. The phenotype of homozygotes, jet black, is equivalent to the phenotype of mice homozygous for extreme nonagouti, a^e.

References

• Original: J:10399 Woychik RP, et al., Molecular and genetic characterization of a radiation-induced structural rearrangement in mouse chromosome 2 causing mutations at the limb deformity and agouti loci. Proc Natl Acad Sci U S A. 1990 Apr;87(7):2588-92
• All: 3 reference(s)