Egr4^tm1Jmi
Targeted Allele Detail

Summary

• Symbol: Egr4^tm1Jmi
• Name: early growth response 4; targeted mutation 1, Jeffrey Milbrandt
• MGI ID: MGI:2450146
• Gene: Egr4 Location: Chr6:85488103-85490571 bp, - strand Genetic Position: Chr6, 37.48 cM
• Alliance: Egr4^tm1Jmi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:58099
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The insertion of a neomycin selection cassette deleted a portion of the zinc finger binding domain and precluded the translation of downstream amino acids. While normal transcript was undetected by Northern blot analysis of homozygous mutant brain and testis tissue, low levels of a transcript encoding 5' amino acids and a portion of neo was observed. (J:58099)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Egr4 Mutation: 13 strains or lines available

References

• Original: J:58099 Tourtellotte WG, et al., Infertility associated with incomplete spermatogenic arrest and oligozoospermia in Egr4-deficient mice. Development. 1999 Nov;126(22):5061-71
• All: 5 reference(s)