Prx^tm1Brp
Targeted Allele Detail

Summary

• Symbol: Prx^tm1Brp
• Name: periaxin; targeted mutation 1, Peter Brophy
• MGI ID: MGI:2450150
• Synonyms: Prx^-
• Gene: Prx Location: Chr7:27198730-27219466 bp, + strand Genetic Position: Chr7, 15.91 cM
• Alliance: Prx^tm1Brp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:62566
• Parent Cell Line: CGR8 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A fragment extending from within exon 6 through a portion of exon 7 (corresponding to cDNA nt 611 through 3440) was replaced with a neomycin selection cassette inserted by homologous recombination. An absence L and S isoforms was verifed on both mRNA and protein levels by Northern and Western blot analyses of sciatic nerves. (J:62566)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Prx Mutation: 45 strains or lines available

References

• Original: J:62566 Gillespie CS, et al., Peripheral demyelination and neuropathic pain behavior in periaxin-deficient mice. Neuron. 2000 May;26(2):523-31
• All: 10 reference(s)