Csnk2b^tm1.1Bb
Targeted Allele Detail

Summary

• Symbol: Csnk2b^tm1.1Bb
• Name: casein kinase 2, beta polypeptide; targeted mutation 1.1, Brigitte Boldyreff
• MGI ID: MGI:2450157
• Synonyms: CK2Beta^2lox
• Gene: Csnk2b Location: Chr17:35335172-35341029 bp, - strand Genetic Position: Chr17, 18.59 cM
• Alliance: Csnk2b^tm1.1Bb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:81637
• Parent Cell Line: AT1 (ES Cell)
• Strain of Origin: 129S2/SvPasCrl

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Cre-mediated excision of the floxed neo cassette from Csnk2b^tm1Bb left the promoter and exons 1 and 2 flanked by single loxP sites. Western blot analysis of ES cells harboring this allele indicated that the presence of the loxP sites did not interfere with protein expression. (J:81637)

Expression

In Mice Carrying this Mutation:	2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	10 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Csnk2b Mutation: 14 strains or lines available

References

• Original: J:81637 Buchou T, et al., Disruption of the regulatory Beta subunit of protein kinase CK2 in mice leads to a cell-autonomous defect and early embryonic lethality. Mol Cell Biol. 2003 Feb;23(3):908-15
• All: 9 reference(s)