Txn2^{Gt(OST69169)Lex}
Gene trapped Allele Detail

Summary

• Symbol: Txn2^{Gt(OST69169)Lex}
• Name: thioredoxin 2; gene trap OST69169, Lexicon Genetics
• MGI ID: MGI:2450237
• Synonyms: Trx-2^-, Txn2^{Gt(VICTR24)1Lex}
• Gene: Txn2 Location: Chr15:77799251-77813194 bp, - strand Genetic Position: Chr15, 36.92 cM
• Alliance: Txn2^{Gt(OST69169)Lex} page

Mutation origin

• Mutant Cell Line: OST69169
• Germline Transmission: Earliest citation of germline transmission: J:81638
• Parent Cell Line: Lex-1 (ES Cell)
• Strain of Origin: 129S5/SvEvBrd
• Project Collection: Lexicon

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector
• Mutation details: A gene trap vector consisting of LTR sites flanking a Beta-geo cassette and a PGK-neo cassette integrated 301 bp upstream of exon 1. Protein was undetected by Western blot analysis of homozygous mutant embryos. Reduced levels of protein were observed in various tissues obtained from heterozygous mice. (J:81638)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  OST69169	CG515110 ; (MGI Seq Detail)	3' RACE	Chr15:77811886-77812377 bp (-)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  18 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Txn2 Mutation: 26 strains or lines available

References

• Original: J:81638 Nonn L, et al., The absence of mitochondrial thioredoxin 2 causes massive apoptosis, exencephaly, and early embryonic lethality in homozygous mice. Mol Cell Biol. 2003 Feb;23(3):916-22
• All: 5 reference(s)