Tg(KRT18-cre/ERT2)1Rgo
Transgene Detail

Summary

• Symbol: Tg(KRT18-cre/ERT2)1Rgo
• Name: transgene insertion 1, Robert G Oshima
• MGI ID: MGI:2450291
• Synonyms: K18CreER, K18iresCreER^T2
• Transgene: Tg(KRT18-cre/ERT2)1Rgo Location: unknown
• Alliance: Tg(KRT18-cre/ERT2)1Rgo page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Tg(KRT18-cre/ERT2)1Rgo expression driven by 1 gene
  Transgene expression driven by:
  

  Organism

  Driver Gene

  Homolog in Mouse

  Note

  human

  KRT18 (3875)

  Krt18

  (MGI:96692)

• Mutation details: The transgenic construct encodes a tamoxifen-inducible fusion protein consisting of cre recombinase and a mutated human estrogen receptor ligand-binding domain inserted into exon 7 of human KRT18. Human KRT18 regulatory sequences were used to drive transgene expression in epithelial cells. (J:81652)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	KRT18 (human) Summary of all recombinase alleles driven by KRT18. Comparative matrix view of recombinase activities Alliance human KRT18 gene page

Tumor Data

List all tumor models in MMHCdb carrying Tg(KRT18-cre/ERT2)1Rgo

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:81652 Wen F, et al., Expression of conditional cre recombinase in epithelial tissues of transgenic mice. Genesis. 2003 Feb;35(2):100-6
• All: 4 reference(s)