Tph1^tm1Bdr
Targeted Allele Detail

Summary

• Symbol: Tph1^tm1Bdr
• Name: tryptophan hydroxylase 1; targeted mutation 1, Michael Bader
• MGI ID: MGI:2450301
• Synonyms: Tph^-, Tph1^-
• Gene: Tph1 Location: Chr7:46294065-46321961 bp, - strand Genetic Position: Chr7, 30.43 cM
• Alliance: Tph1^tm1Bdr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:81435
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: An isoform specific disruption of the endogenous allele was achieved by the insertion of neomycin and thymidine kinase cassettes via homologous recombination. The disruption putatively resulted in functional ablation in the peripheral tissues. The endogenous allele encodes the rate-limiting enzyme for serotonin synthesis, and while serotonin was detected at normal levels in the brain, it was absent in the periphery, with the exception of low levels (4% of wild-type) detected in the duodenum. (J:81435)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tph1 Mutation: 41 strains or lines available

References

• Original: J:81435 Walther DJ, et al., Synthesis of serotonin by a second tryptophan hydroxylase isoform. Science. 2003 Jan 3;299(5603):76
• All: 35 reference(s)