Tg(Tek-cre/ERT2)1Arnd
Transgene Detail

Summary

• Symbol: Tg(Tek-cre/ERT2)1Arnd
• Name: transgene insertion 1, Bernd Arnold
• MGI ID: MGI:2450312
• Synonyms: L43Tie2Cre^T2, Tg(Tek-cre/ESR1)1Arnd, Tie2-CreER^T2, Tie2ER^T2Cre
• Transgene: Tg(Tek-cre/ERT2)1Arnd Location: unknown
• Alliance: Tg(Tek-cre/ERT2)1Arnd page

Transgene origin

• Strain of Origin: (C57BL/6 x DBA/2)

Transgene description

• Transgene Type: Transgenic (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Tg(Tek-cre/ERT2)1Arnd expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Tek (MGI:98664)

• Mutation details: The transgenic construct encodes a tamoxifen-inducible fusion protein consisting of cre recombinase and a mutated human estrogen receptor ligand-binding domain fused to the mouse Tek promoter and 10.5 kb of the first intron. Transgene expression in endothelial cells of the liver and kidney was confirmed by immunohistochemical analysis. (J:81649)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Tek (mouse) Summary of all recombinase alleles driven by Tek. Comparative matrix view of recombinase activities Alliance mouse Tek gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

Notes

Two transgenic lines displaying endothelial-specific transgene expression, designated L34 and L43, were created.

References

• Original: J:81649 Forde A, et al., Temporal Cre-mediated recombination exclusively in endothelial cells using Tie2 regulatory elements. Genesis. 2002 Aug;33(4):191-7
• All: 43 reference(s)