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Tg(Tek-cre/ERT2)1Arnd
Transgene Detail
Summary
Symbol: Tg(Tek-cre/ERT2)1Arnd
Name: transgene insertion 1, Bernd Arnold
MGI ID: MGI:2450312
Synonyms: L43Tie2CreT2, Tg(Tek-cre/ESR1)1Arnd, Tie2-CreERT2, Tie2ERT2Cre
Transgene: Tg(Tek-cre/ERT2)1Arnd  Location: unknown  
Alliance: Tg(Tek-cre/ERT2)1Arnd page
Transgene
origin
Strain of Origin:  (C57BL/6 x DBA/2)
Transgene
description
Transgene Type:    Transgenic (Inducible, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
 
Tg(Tek-cre/ERT2)1Arnd expression driven by 1 gene
 
Mutation detailsThe transgenic construct encodes a tamoxifen-inducible fusion protein consisting of cre recombinase and a mutated human estrogen receptor ligand-binding domain fused to the mouse Tek promoter and 10.5 kb of the first intron. Transgene expression in endothelial cells of the liver and kidney was confirmed by immunohistochemical analysis. (J:81649)
Recombinase
activity
Activity:
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Driver: Tek (mouse)
Summary of all recombinase alleles driven by Tek.
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Notes
Two transgenic lines displaying endothelial-specific transgene expression, designated L34 and L43, were created.
References
Original:  J:81649 Forde A, et al., Temporal Cre-mediated recombination exclusively in endothelial cells using Tie2 regulatory elements. Genesis. 2002 Aug;33(4):191-7
All:  43 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory