Hba^tm1Paz
Targeted Allele Detail

Summary

• Symbol: Hba^tm1Paz
• Name: hemoglobin alpha chain complex; targeted mutation 1, Chris Paszty
• MGI ID: MGI:2450531
• Synonyms: Hba⁰, Hba^1-2del
• Gene: Hba Location: unknown Genetic Position: Chr11, cytoband A

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:28392
• Parent Cell Line: AB1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Hba^tm1Paz involves 2 genes/genome features (Hba-a1, Hba-a2) View all
• Mutation details: Both of the adult hemoglobin genes, alpha 1 and alpha 2, and the region between them were deleted and replaced with a neomycin resistance cassette by homologous recombination. (J:28392)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Hba Mutation: 10 strains or lines available

References

• Original: J:28392 Paszty C, et al., Lethal alpha-thalassaemia created by gene targeting in mice and its genetic rescue. Nat Genet. 1995 Sep;11(1):33-9
• All: 113 reference(s)