Tg(LIPG)1Tq
Transgene Detail

Summary

• Symbol: Tg(LIPG)1Tq
• Name: transgene insertion 1, Thomas Quertermous
• MGI ID: MGI:2450675
• Synonyms: hLIPGTg
• Transgene: Tg(LIPG)1Tq Location: unknown
• Alliance: Tg(LIPG)1Tq page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(LIPG)1Tq expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  LIPG (9388)

  Lipg	(MGI:1341803)

• Mutation details: A 196 kb BAC carrying the human LIPG genomic sequence was used for the transgene. Transgene expression in brain, aorta, heart, lung, kidney, and spleen was confirmed by RNase protection assay. Transgene mRNA expression and protein expression was determined to be 3.2-fold and 1.9-fold that of endogenous mouse mRNA and protein expression, respectively. (J:81821)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:81821 Ishida T, et al., Endothelial lipase is a major determinant of HDL level. J Clin Invest. 2003 Feb;111(3):347-55
• All: 4 reference(s)