Ccr8^tm1Gma
Targeted Allele Detail

Summary

• Symbol: Ccr8^tm1Gma
• Name: C-C motif chemokine receptor 8; targeted mutation 1, Gabriel Marquez
• MGI ID: MGI:2450726
• Synonyms: CCR8^-
• Gene: Ccr8 Location: Chr9:119921199-119923972 bp, + strand Genetic Position: Chr9, 71.39 cM, cytoband F4
• Alliance: Ccr8^tm1Gma page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:81812
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced 508 bp preceding the ATG start site and the first 658 bp of the coding sequence. Absence of gene expression in homozygous mutant animals was confirmed by RT-PCR analysis of total thymus RNA. (J:81812)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Ccr8 Mutation: 41 strains or lines available

References

• Original: J:81812 Goya I, et al., Absence of CCR8 Does Not Impair the Response to Ovalbumin-Induced Allergic Airway Disease. J Immunol. 2003 Feb 15;170(4):2138-46
• All: 2 reference(s)