Htr7^tm1Sut
Targeted Allele Detail

Summary

• Symbol: Htr7^tm1Sut
• Name: 5-hydroxytryptamine (serotonin) receptor 7; targeted mutation 1, J Gregor Sutcliffe
• MGI ID: MGI:2450732
• Synonyms: 5-HT7^-
• Gene: Htr7 Location: Chr19:35936134-36034907 bp, - strand Genetic Position: Chr19, 30.3 cM
• Alliance: Htr7^tm1Sut page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:81842
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: The gene was disrupted by insertion of a neomycin resistance gene into exon 2 via homologous recombination. Northern blot analysis detected mutant transcripts in homozygous mutant animals. It is believed that no functional product is encoded by the mutant transcript due to multiple stop codons within the sequence. (J:81842)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Htr7 Mutation: 33 strains or lines available

References

• Original: J:81842 Hedlund PB, et al., No hypothermic response to serotonin in 5-HT7 receptor knockout mice. Proc Natl Acad Sci U S A. 2003 Feb 4;100(3):1375-80
• All: 22 reference(s)