Tal1^tm3Wehi
Targeted Allele Detail

Summary

• Symbol: Tal1^tm3Wehi
• Name: T cell acute lymphocytic leukemia 1; targeted mutation 3, Walter and Eliza Hall, Institute of Medical Research
• MGI ID: MGI:2450743
• Synonyms: Scl^fl, SCL^loxP
• Gene: Tal1 Location: Chr4:114913623-114928952 bp, + strand Genetic Position: Chr4, 52.73 cM
• Alliance: Tal1^tm3Wehi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:81826
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A floxed neomycin resistance cassette was inserted into intron 6 and a single loxP site was introduced into the non-coding region of exon 6 via homologous recombination. The floxed neo cassette was removed by mating mutant animals to cre deleter strain TgN(EIIa-cre)C5379Lmgd, leaving behind a single loxP site in intron 6 and a single loxP site in exon 6. (J:81826)

Expression

In Mice Carrying this Mutation:	5 assay results 3 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tal1 Mutation: 33 strains or lines available

References

• Original: J:81826 Hall MA, et al., The critical regulator of embryonic hematopoiesis, SCL, is vital in the adult for megakaryopoiesis, erythropoiesis, and lineage choice in CFU-S12. Proc Natl Acad Sci U S A. 2003 Feb 4;100(3):992-7
• All: 16 reference(s)