Mep1b^tm1Bond
Targeted Allele Detail

Summary

• Symbol: Mep1b^tm1Bond
• Name: meprin 1 beta; targeted mutation 1, Judith S Bond
• MGI ID: MGI:2450870
• Synonyms: beta^-
• Gene: Mep1b Location: Chr18:21205401-21233256 bp, + strand Genetic Position: Chr18, 11.81 cM
• Alliance: Mep1b^tm1Bond page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:81815
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: The gene was disrupted by insertion of a neomycin resistance cassette into the protease domain encoded by exon 7 via homologous recombination. (J:81815)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mep1b Mutation: 44 strains or lines available

References

• Original: J:81815 Norman LP, et al., Targeted disruption of the meprin Beta gene in mice leads to underrepresentation of knockout mice and changes in renal gene expression profiles. Mol Cell Biol. 2003 Feb;23(4):1221-30
• All: 23 reference(s)