Ube2a^tm1Agr
Targeted Allele Detail

Summary

• Symbol: Ube2a^tm1Agr
• Name: ubiquitin-conjugating enzyme E2A; targeted mutation 1, J Anton Grootegoed
• MGI ID: MGI:2450874
• Synonyms: HR6A-, mHR6A^-
• Gene: Ube2a Location: ChrX:36137948-36147875 bp, + strand Genetic Position: ChrX, 21.28 cM
• Alliance: Ube2a^tm1Agr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:81811
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The ORF was disrupted immediately after the ATG as a neo was inserted in place of sequence encoding amino acids 3-14 in exon 1. PCR confirmed recombination in mutant mice and RT-PCR indicated lack of transcript in mouse testis. (J:91848)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ube2a Mutation: 6 strains or lines available

References

• Original: J:81811 Baarends WM, et al., Loss of HR6B Ubiquitin-Conjugating Activity Results in Damaged Synaptonemal Complex Structure and Increased Crossing-Over Frequency during the Male Meiotic Prophase. Mol Cell Biol. 2003 Feb;23(4):1151-62
• All: 3 reference(s)