Soat2^tm1Far
Targeted Allele Detail

Summary

• Symbol: Soat2^tm1Far
• Name: sterol O-acyltransferase 2; targeted mutation 1, Bob Farese
• MGI ID: MGI:2450875
• Synonyms: ACAT2
• Gene: Soat2 Location: Chr15:102058961-102071904 bp, + strand Genetic Position: Chr15, 57.33 cM
• Alliance: Soat2^tm1Far page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:82032
• Parent Cell Line: RF8 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The gene was disrupted by replacement of 1.5 kb of 3' sequences with a neomycin resistance cassette by homologous recombination. The gene targeting event results in deletion of 28% of the protein coding sequence. Absence of gene expression in homozygous mutant animals was confirmed by RT-PCR analysis of mRNA from liver and small intestines. (J:82032)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Soat2 Mutation: 40 strains or lines available

References

• Original: J:82032 Buhman KK, et al., Resistance to diet-induced hypercholesterolemia and gallstone formation in ACAT2-deficient mice. Nat Med. 2000 Dec;6(12):1341-7
• All: 19 reference(s)