Swap70^tm1Jess
Targeted Allele Detail

Summary

• Symbol: Swap70^tm1Jess
• Name: SWA-70 protein; targeted mutation 1, Rolf Jessberger
• MGI ID: MGI:2450881
• Synonyms: Swap-, SWAP-70^ko
• Gene: Swap70 Location: Chr7:109820918-109882713 bp, + strand Genetic Position: Chr7, 57.7 cM
• Alliance: Swap70^tm1Jess page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:71160
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 2.7 kb fragment encompassing a portion of the 5' UTR and all of exon 1 was replaced with a PGK-neo cassette inserted by homologous recombination. Normal protein was undetected by Western blot analysis of LPS-activated splenic B cells obtained from homozygous mutant mice. (J:71160)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Swap70 Mutation: 33 strains or lines available

References

• Original: J:71160 Borggrefe T, et al., Impaired IgE response in SWAP-70-deficient mice. Eur J Immunol. 2001 Aug;31(8):2467-75
• All: 26 reference(s)