Il17ra^tm1Koll
Targeted Allele Detail

Summary

• Symbol: Il17ra^tm1Koll
• Name: interleukin 17 receptor A; targeted mutation 1, Jay K Kolls
• MGI ID: MGI:2450882
• Synonyms: IL-17R^-, Il17ra^Amgen, IL-17R KO
• Gene: Il17ra Location: Chr6:120440143-120460692 bp, + strand Genetic Position: Chr6, 56.95 cM
• Alliance: Il17ra^tm1Koll page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:71097
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 5.7 kb genomic fragment encompassing exons 4 through 11 was replaced with a PGK-neo cassette inserted by homologous recombination. The deleted region corresponds with nt 445 through 1172 of the cDNA. Absence of the normal protein in homozygous mutant mice was indicated by flow cytometric analysis of spleen and peritoneal exudate cells. (J:71097)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Il17ra Mutation: 47 strains or lines available

References

• Original: J:71097 Ye P, et al., Requirement of interleukin 17 receptor signaling for lung CXC chemokine and granulocyte colony-stimulating factor expression, neutrophil recruitment, and host defense. J Exp Med. 2001 Aug 20;194(4):519-27
• All: 161 reference(s)