Tec^tm1Welm
Targeted Allele Detail

Summary

• Symbol: Tec^tm1Welm
• Name: tec protein tyrosine kinase; targeted mutation 1, Wilfred Ellmeier
• MGI ID: MGI:2450883
• Synonyms: Tec^-
• Gene: Tec Location: Chr5:72913059-73025826 bp, - strand Genetic Position: Chr5, 38.44 cM
• Alliance: Tec^tm1Welm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:66080
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The insertion of a neomycin selection cassette disrupted the endogenous allele by replacing exon 2 and surrounding intronic sequence. The deleted exon contained the start codon, encoded 45 residues of the Pleckstrin homology domain, and is common to the 4 known isoforms. Western blot analysis showed an absence of full length and truncated protein. (J:66080)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tec Mutation: 43 strains or lines available

References

• Original: J:66080 Ellmeier W, et al., Severe B cell deficiency in mice lacking the tec kinase family members tec and Btk. J Exp Med. 2000 Dec 4;192(11):1611-24
• All: 12 reference(s)