Tec^tm1Welm
Targeted Allele Detail

Summary

• Symbol: Tec^tm1Welm
• Name: tec protein tyrosine kinase; targeted mutation 1, Wilfred Ellmeier
• MGI ID: MGI:2450883
• Synonyms: Tec^-
• Gene: Tec Location: Chr5:72913059-73025826 bp, - strand Genetic Position: Chr5, 38.44 cM
• Alliance: Tec^tm1Welm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:66080
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The insertion of a neomycin selection cassette disrupted the endogenous allele by replacing exon 2 and surrounding intronic sequence. The deleted exon contained the start codon, encoded 45 residues of the Pleckstrin homology domain, and is common to the 4 known isoforms. Western blot analysis showed an absence of full length and truncated protein. (J:66080)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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hm1	Tec^tm1Welm/Tec^tm1Welm	involves: 129P2/OlaHsd * C57BL/6
cx2  Disease Model	Btk^tm1Wk/Btk^tm1Wk Tec^tm1Welm/Tec^tm1Welm	involves: 129P2/OlaHsd * C57BL/6

Phenotypes:

Affected Systems	hm1	cx2
show or hide all annotated terms Sex:
cellular		√
decreased B cell proliferation		√
hematopoietic system	√	√
decreased B cell proliferation		√
abnormal B cell differentiation		√
decreased B cell number		√
increased pre-B cell number		√
abnormal spleen morphology		√
abnormal spleen white pulp morphology		√
abnormal spleen marginal zone morphology		√
decreased immunoglobulin level		√
decreased IgG2a level		√
decreased IgG3 level		√
decreased IgM level		√
abnormal platelet physiology		√
decreased platelet aggregation	√	√
homeostasis/metabolism	√	√
abnormal platelet physiology		√
decreased platelet aggregation	√	√
immune system	N	√
immune system phenotype	N
decreased B cell proliferation		√
abnormal B cell differentiation		√
decreased B cell number		√
increased pre-B cell number		√
abnormal spleen morphology		√
abnormal spleen white pulp morphology		√
abnormal spleen marginal zone morphology		√
abnormal humoral immune response		√
decreased immunoglobulin level		√
decreased IgG2a level		√
decreased IgG3 level		√
decreased IgM level		√

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Key:

√

disease model

expected model not found

Models:

Human Diseases	cx2
X-linked agammaglobulinemia IDs X-linked agammaglobulinemia       DOID:14179 MESH:C537409 NCI:C3822 OMIM:300755 ORDO:47 UMLS_CUI:C0221026 Close	√

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tec Mutation: 43 strains or lines available

References

• Original: J:66080 Ellmeier W, et al., Severe B cell deficiency in mice lacking the tec kinase family members tec and Btk. J Exp Med. 2000 Dec 4;192(11):1611-24
• All: 12 reference(s)