Hhip^tm1Amc
Targeted Allele Detail

Summary

• Symbol: Hhip^tm1Amc
• Name: Hedgehog-interacting protein; targeted mutation 1, Andrew P McMahon
• MGI ID: MGI:2450891
• Synonyms: Hip1-
• Gene: Hhip Location: Chr8:80692480-80784635 bp, - strand Genetic Position: Chr8, 37.95 cM, cytoband C3
• Alliance: Hhip^tm1Amc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:81798
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The endogenous locus was disrupted by the insertion of cassette containing lacZ and PGK-neo genes. The start codon and downstream sequences were deleted from exon 1. The expression pattern of beta-galactosidase was similar to that of the endogenous gene. (J:81798)

Expression

In Mice Carrying this Mutation:	40 assay results
In Structures Affected by this Mutation:	11 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Hhip Mutation: 44 strains or lines available

References

• Original: J:81798 Chuang PT, et al., Feedback control of mammalian Hedgehog signaling by the Hedgehog-binding protein, Hip1, modulates Fgf signaling during branching morphogenesis of the lung. Genes Dev. 2003 Feb 1;17(3):342-7
• All: 17 reference(s)