Six3^tm1Gco
Targeted Allele Detail

Summary

• Symbol: Six3^tm1Gco
• Name: sine oculis-related homeobox 3; targeted mutation 1, Guillermo Oliver
• MGI ID: MGI:2450901
• Synonyms: Six3^-
• Gene: Six3 Location: Chr17:85921036-85933619 bp, + strand Genetic Position: Chr17, 55.42 cM
• Alliance: Six3^tm1Gco page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:81797
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: The endogenous allele was disrupted by the in frame insertion of Beta-gal and neo 22 codons downstream of the start codon. An absence of protein in homozygous mutant mice was indicated by immunofluorescence. (J:81797)

Disease models

Expression

In Mice Carrying this Mutation:	1 assay results
In Structures Affected by this Mutation:	9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Six3 Mutation: 13 strains or lines available

References

• Original: J:81797 Lagutin OV, et al., Six3 repression of Wnt signaling in the anterior neuroectoderm is essential for vertebrate forebrain development. Genes Dev. 2003 Feb 1;17(3):368-79
• All: 7 reference(s)