Wnt3^tm2Amc
Targeted Allele Detail

Summary

• Symbol: Wnt3^tm2Amc
• Name: wingless-type MMTV integration site family, member 3; targeted mutation 2, Andrew P McMahon
• MGI ID: MGI:2450903
• Synonyms: Wnt3^c
• Gene: Wnt3 Location: Chr11:103664976-103708783 bp, + strand Genetic Position: Chr11, 67.5 cM
• Alliance: Wnt3^tm2Amc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:81795
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A 5' loxP site was introduced into intron 2 and a 3' loxP site was introduced into intron 4 via homologous recombination. An frt-flanked neo cassette was also introduced into the 3' site for positive selection. (J:81795)

Expression

In Mice Carrying this Mutation:	52 assay results
In Structures Affected by this Mutation:	5 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Wnt3^tm2Amc

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Wnt3 Mutation: 25 strains or lines available

References

• Original: J:81795 Barrow JR, et al., Ectodermal Wnt3/beta-catenin signaling is required for the establishment and maintenance of the apical ectodermal ridge. Genes Dev. 2003 Feb 1;17(3):394-409
• All: 9 reference(s)