Msi1^tm1Okn
Targeted Allele Detail

Summary

• Symbol: Msi1^tm1Okn
• Name: musashi RNA-binding protein 1; targeted mutation 1, Hideyuki Okano
• MGI ID: MGI:2450917
• Synonyms: msi1^-
• Gene: Msi1 Location: Chr5:115567734-115593757 bp, + strand Genetic Position: Chr5, 56.09 cM, cytoband E3-F
• Alliance: Msi1^tm1Okn page

Development of hydrocephalus in postnatal Msi1^tm1Okn/Msi1^tm1Okn mice

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:81794
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The gene was disrupted by replacment of a 4.2 kb genomic region (encoding the translation initiation site and the first RNA recognition motif) with a neomycin resistance cassette via homologous recombination. Western blot analysis of embryonic and neonatal brain proteins confirmed the absence of gene expression in homozygous mutant animals. (J:81794)

Expression

In Structures Affected by this Mutation:

9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Msi1 Mutation: 31 strains or lines available

References

• Original: J:81794 Sakakibara S, et al., RNA-binding protein Musashi family: roles for CNS stem cells and a subpopulation of ependymal cells revealed by targeted disruption and antisense ablation. Proc Natl Acad Sci U S A. 2002 Nov 12;99(23):15194-9
• All: 5 reference(s)