Surf1^tm1Zev
Targeted Allele Detail

Summary

• Symbol: Surf1^tm1Zev
• Name: surfeit gene 1; targeted mutation 1, Massimo Zeviani
• MGI ID: MGI:2450930
• Synonyms: Surf1^-/-
• Gene: Surf1 Location: Chr2:26803393-26806542 bp, - strand Genetic Position: Chr2, 19.1 cM
• Alliance: Surf1^tm1Zev page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:81773
• Parent Cell Line: AB1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 5, 6, and 7 were replaced with a neomycin selection cassette inserted by homologous recombination. Normal transcript was undetected by RT-PCR analysis of mRNA obtained from homozygous mutant embryos. Western blot analysis of mitochondrial extracts obtained from cultured homozygous mutant fibroblasts indicated an absence of protein. (J:81773)

Disease models

Expression

In Mice Carrying this Mutation:	31 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Surf1 Mutation: 14 strains or lines available

References

• Original: J:81773 Agostino A, et al., Constitutive knockout of Surf1 is associated with high embryonic lethality, mitochondrial disease and cytochrome c oxidase deficiency in mice. Hum Mol Genet. 2003 Feb 15;12(4):399-413
• All: 4 reference(s)