Tab2^tm1Aki
Targeted Allele Detail

Summary

• Symbol: Tab2^tm1Aki
• Name: TGF-beta activated kinase 1/MAP3K7 binding protein 2; targeted mutation 1, Shizuo Akira
• MGI ID: MGI:2450936
• Synonyms: TAB2^-
• Gene: Tab2 Location: Chr10:7781417-7831994 bp, - strand Genetic Position: Chr10, 2.56 cM
• Alliance: Tab2^tm1Aki page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:81816
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Flanking loxP sites were introduced to the large exon and a floxed neo cassette was inserted into the upstream intron. Transient expression of cre recombinase in correctly targeted ES cells resulted in deletion of the floxed neo cassette leaving behind loxP sites flanking the large exon. Mutant animals were then mated to cre deleter strain Tg(ACTB-cre)13Miya to generate null animals. (J:81816)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tab2 Mutation: 31 strains or lines available

References

• Original: J:81816 Sanjo H, et al., TAB2 is essential for prevention of apoptosis in fetal liver but not for interleukin-1 signaling. Mol Cell Biol. 2003 Feb;23(4):1231-8
• All: 3 reference(s)