Asic3^tm1Pig
Targeted Allele Detail

Summary

• Symbol: Asic3^tm1Pig
• Name: acid-sensing ion channel 3; targeted mutation 1, Andreas Zimmer
• MGI ID: MGI:2451051
• Synonyms: ASIC3^-
• Gene: Asic3 Location: Chr5:24618449-24622836 bp, + strand Genetic Position: Chr5, 11.72 cM
• Alliance: Asic3^tm1Pig page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:81785
• Parent Cell Line: MPI-II (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The gene was disrupted by replacement of exons 2-11 with a lacZ-neo cassette via homologous recombination. The targeted mutation results in deletion of the second transmembrane domain as well as most of the extracellular domain. Absence of gene expression in homozygous mutant animals was confirmed by Northern blot analysis of dorsal root ganglion cells using a probe to exon 1. (J:81785)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Asic3 Mutation: 30 strains or lines available

References

• Original: J:81785 Chen CC, et al., A role for ASIC3 in the modulation of high-intensity pain stimuli. Proc Natl Acad Sci U S A. 2002 Jun 25;99(13):8992-7
• All: 14 reference(s)