Itga1^tm1Gdnr
Targeted Allele Detail

Summary

• Symbol: Itga1^tm1Gdnr
• Name: integrin alpha 1; targeted mutation 1, Humphrey Gardner
• MGI ID: MGI:2451067
• Synonyms: alpha1^-
• Gene: Itga1 Location: Chr13:115094615-115238500 bp, - strand Genetic Position: Chr13, 64.61 cM
• Alliance: Itga1^tm1Gdnr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:32930
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: The gene was disrupted by insertion of a PGK-neo cassette in the reverse orientation into a coding exon via homologous recombination. Absence of gene expression in homozygous mutant animals was confirmed by immunoprecipitation immunoblot and immunohistochemical analysis. (J:32930)

Disease models

Expression

In Mice Carrying this Mutation:	7 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Itga1 Mutation: 66 strains or lines available

References

• Original: J:32930 Gardner H, et al., Deletion of integrin alpha 1 by homologous recombination permits normal murine development but gives rise to a specific deficit in cell adhesion. Dev Biol. 1996 May 1;175(2):301-13
• All: 33 reference(s)