Kcnc1^tm1Joho
Targeted Allele Detail

Summary

• Symbol: Kcnc1^tm1Joho
• Name: potassium voltage gated channel, Shaw-related subfamily, member 1; targeted mutation 1, Rolf H Joho
• MGI ID: MGI:2451092
• Synonyms: Kv3.1^-
• Gene: Kcnc1 Location: Chr7:46045921-46088128 bp, + strand Genetic Position: Chr7, 30.1 cM
• Alliance: Kcnc1^tm1Joho page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:38598
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The gene was disrupted by replacement of 35 bp of the S2-S3 linker sequence with a PGK-neo cassette via homologous recombination. Absence of gene expression in homozygous mutant animals was confirmed by Western blot analysis of brain proteins. (J:38598)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kcnc1 Mutation: 41 strains or lines available

References

• Original: J:38598 Ho CS, et al., Pleiotropic effects of a disrupted K+ channel gene: reduced body weight, impaired motor skill and muscle contraction, but no seizures. Proc Natl Acad Sci U S A. 1997 Feb 18;94(4):1533-8
• All: 23 reference(s)