Jchain^tm1Tl
Targeted Allele Detail

Summary

• Symbol: Jchain^tm1Tl
• Name: immunoglobulin joining chain; targeted mutation 1, Tomas Leanderson
• MGI ID: MGI:2451101
• Synonyms: JDTA
• Gene: Jchain Location: Chr5:88667663-88675667 bp, - strand Genetic Position: Chr5, 43.7 cM
• Alliance: Jchain^tm1Tl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:71355
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted
• Mutations: Deletion, Insertion
• Jchain^tm1Tl involves 1 genes/genome features (Jchain) View all
• Mutation details: The gene was disrupted by replacement of exon 1 with a diphtheria toxin A (DTA) chain gene and a floxed neomycin resistance cassette. The exon 1 splice site is situated 3' to the neo cassette. The floxed neo cassette was removed by transient expression of cre recombinase in correctly targeted ES cells, thus allowing transcription from the DTA gene. (J:71355)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Jchain Mutation: 24 strains or lines available

References

• Original: J:71355 Erlandsson L, et al., Joining chain-expressing and -nonexpressing B cell populations in the mouse. J Exp Med. 2001 Sep 3;194(5):557-70
• All: 1 reference(s)