Pde4d^tm1Mct
Targeted Allele Detail

Summary

• Symbol: Pde4d^tm1Mct
• Name: phosphodiesterase 4D, cAMP specific; targeted mutation 1, Marco Conti
• MGI ID: MGI:2451168
• Synonyms: 4DKO, PDE4D^-
• Gene: Pde4d Location: Chr13:108790711-110092503 bp, + strand Genetic Position: Chr13, 59.69 cM
• Alliance: Pde4d^tm1Mct page

Growth comparison of wild type and Pde4d^tm1Mct/Pde4d^tm1Mct mice

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:58116
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 3.2 kb fragment encompassing exons 8 and 9 was replaced with a PGK-hrpt cassette inserted in the opposite orientation by homologous recombination. The deleted region encoded the catalytic domain. Neither transcript nor protein was detected in homozygous mutant brain tissue by Northern and Western blot analyses. (Corrected information communicated to MGI by author.) (J:58116)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Pde4d Mutation: 185 strains or lines available

References

• Original: J:58116 Jin SL, et al., Impaired growth and fertility of cAMP-specific phosphodiesterase PDE4D-deficient mice. Proc Natl Acad Sci U S A. 1999 Oct 12;96(21):11998-2003
• All: 24 reference(s)