Rin1^tm1Colc
Targeted Allele Detail

Summary

• Symbol: Rin1^tm1Colc
• Name: Ras and Rab interactor 1; targeted mutation 1, John Colcicelli
• MGI ID: MGI:2451226
• Synonyms: Rin1^-
• Gene: Rin1 Location: Chr19:5100509-5107099 bp, + strand Genetic Position: Chr19, 4.23 cM
• Alliance: Rin1^tm1Colc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:81922
• Parent Cell Line: GS1 (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 2 through 7, encoding most of the ABL and RAS binding domains, were replaced with a PGK-neo cassette inserted by homologous recombination. Absence of transcript and protein was indicated by Northern blot, in situ hybridization, Western blot, and immunohistochemical analyses of homozygous mutant mice. (J:81922)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rin1 Mutation: 25 strains or lines available

References

• Original: J:81922 Dhaka A, et al., The RAS effector RIN1 modulates the formation of aversive memories. J Neurosci. 2003 Feb 1;23(3):748-57
• All: 5 reference(s)